Spred1 is required for synaptic plasticity and hippocampus-dependent learning.

  title={Spred1 is required for synaptic plasticity and hippocampus-dependent learning.},
  author={Ellen Denayer and Tariq Ahmed and Hilde Brems and Geeske M van Woerden and Nils Zuiderveen Borgesius and Zsuzsanna Callaerts-Vegh and Akihiko Yoshimura and Dieter Hartmann and Ype Elgersma and Rudi D'hooge and Eric Legius and Detlef Balschun},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={28 53},
Germline mutations in SPRED1, a negative regulator of Ras, have been described in a neurofibromatosis type 1 (NF1)-like syndrome (NFLS) that included learning difficulties in some affected individuals. NFLS belongs to the group of phenotypically overlapping neuro-cardio-facial-cutaneous syndromes that are all caused by germ line mutations in genes of the Ras/mitogen-activated protein kinase extracellular signal-regulated kinase (ERK) pathway and that present with some degree of learning… CONTINUE READING


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