Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells.

@article{Nonami2004Spred1NR,
  title={Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells.},
  author={Atsushi Nonami and Reiko Kato and Koji Taniguchi and Daigo Yoshiga and Takaharu Taketomi and Satoru Fukuyama and M. D. N. Harada and Atsuo Sasaki and Akihiko Yoshimura},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 50},
  pages={52543-51}
}
Sprouty/Spred family proteins have been identified as negative regulators of growth factor-induced ERK/mitogen-activated protein (MAP) kinase activation. However, it has not been clarified whether these proteins regulate cytokine-induced ERK activity. We found that Spred-1 is highly expressed in interleukin-3 (IL-3)-dependent hematopoietic cell lines and bone marrow-derived mast cells. To investigate the roles of Spred-1 in hematopoiesis, we expressed wild-type Spred-1 and a dominant negative… CONTINUE READING

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