Spreading of neurodegenerative pathology via neuron-to-neuron transmission of β-amyloid.

@article{Nath2012SpreadingON,
  title={Spreading of neurodegenerative pathology via neuron-to-neuron transmission of β-amyloid.},
  author={Shriram V. Nath and Lotta Agholme and Firoz Roshan Kurudenkandy and Bj{\"o}rn Granseth and Jan Marcusson and Martin Hallbeck},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 26},
  pages={
          8767-77
        }
}
Alzheimer's disease (AD) is the major cause of dementia. During the development of AD, neurofibrillary tangles progress in a fixed pattern, starting in the transentorhinal cortex followed by the hippocampus and cortical areas. In contrast, the deposition of β-amyloid (Aβ) plaques, which are the other histological hallmark of AD, does not follow the same strict spatiotemporal pattern, and it correlates poorly with cognitive decline. Instead, soluble Aβ oligomers have received increasing… CONTINUE READING

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