Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance

@article{Domert2014SpreadingOA,
  title={Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance},
  author={Jakob Domert and Sahana Bhima Rao and Lotta Agholme and Ann-Christin Brorsson and Jan Marcusson and Martin Hallbeck and Sangeeta Nath},
  journal={Neurobiology of Disease},
  year={2014},
  volume={65},
  pages={82-92}
}
The spreading of pathology through neuronal pathways is likely to be the cause of the progressive cognitive loss observed in Alzheimer's disease (AD) and other neurodegenerative diseases. We have recently shown the propagation of AD pathology via cell-to-cell transfer of oligomeric amyloid beta (Aβ) residues 1-42 (oAβ1-42) using our donor-acceptor 3-D co-culture model. We now show that different Aβ-isoforms (fluorescently labeled 1-42, 3(pE)-40, 1-40 and 11-42 oligomers) can transfer from one… CONTINUE READING
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