Corpus ID: 8731484

Spreading of EGF Receptor Activity into EGF-free Regions and Molecular Therapies of Cancer

@inproceedings{Jentsch2008SpreadingOE,
  title={Spreading of EGF Receptor Activity into EGF-free Regions and Molecular Therapies of Cancer},
  author={Garrit Jentsch and Reiner Kree},
  year={2008}
}
  • Garrit Jentsch, Reiner Kree
  • Published 2008
  • Biology
  • The primary activation of the epidermal growth factor receptor (EGFR) has become a prominent target for molecular therapies against several forms of cancer. But despite considerable progress during the last years, many of its aspects remain poorly understood. Experiments on lateral spreading of receptor activity into ligand-free regions challenge the current standard models of EGFR activation. Here, we propose and study a theoretical model, which explains spreading into ligand-free regions… CONTINUE READING

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