Spreading of Alzheimer's disease inflammatory signaling through soluble micro-RNA.

@article{Lukiw2012SpreadingOA,
  title={Spreading of Alzheimer's disease inflammatory signaling through soluble micro-RNA.},
  author={Walter J. Lukiw and Peter N. Alexandrov and Yuhai Zhao and James A. Hill and Surjyadipta Bhattacharjee},
  journal={Neuroreport},
  year={2012},
  volume={23 10},
  pages={621-6}
}
Alzheimer's disease is a progressive, neurodegenerative disorder that develops within the limbic system, spreading radially into anatomically linked brain association areas as the disease progresses. Analysis of temporal-lobe association of neocortex-derived extracellular fluid and cerebrospinal fluid from Alzheimer's disease patients shows an abundant presence of micro-RNA (miRNA), including the proinflammatory miRNA-146a and miRNA-155. Using a novel and highly sensitive LED-Northern dot-blot… CONTINUE READING