Spreading depression-like depolarization and selective vulnerability of neurons. A brief review.

@article{Somjen1990SpreadingDD,
  title={Spreading depression-like depolarization and selective vulnerability of neurons. A brief review.},
  author={G. G. Somjen and Peter G. Aitken and Maurizio Balestrino and Oscar Herreras and Kumiko Kawasaki},
  journal={Stroke},
  year={1990},
  volume={21 11 Suppl},
  pages={III179-83}
}
If oxygen is withdrawn from rat hippocampal slices, a spreading depression-like response occurs earlier and is of larger amplitude in the CA1 area than in the dentate gyrus. After reoxygenation, recovery of synaptic transmission correlates inversely with the time spent in spreading depression. Recovery occurs more frequently in dentate gyrus than in CA1. Chlorpromazine and the gangliosides GM1 and AGF2 promote recovery from hypoxic depression of synaptic transmission in CA1. Prevention of… CONTINUE READING