Spreading depression and related events are significant sources of neuronal Zn2+ release and accumulation.

@article{Carter2011SpreadingDA,
  title={Spreading depression and related events are significant sources of neuronal Zn2+ release and accumulation.},
  author={Russell E. Carter and Isamu Aiba and Robert M. Dietz and Christian T. Sheline and C. William Shuttleworth},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2011},
  volume={31 4},
  pages={1073-84}
}
Spreading depression (SD) involves coordinated depolarizations of neurons and glia that propagate through the brain tissue. Repetitive SD-like events are common following human ischemic strokes, and are believed to contribute to the enlargement of infarct volume. Accumulation of Zn(2+) is also implicated in ischemic neuronal injury. Synaptic glutamate… CONTINUE READING