Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature.

@article{Ayata2015SpreadingDS,
  title={Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature.},
  author={C. Ayata and M. Lauritzen},
  journal={Physiological reviews},
  year={2015},
  volume={95 3},
  pages={
          953-93
        }
}
  • C. Ayata, M. Lauritzen
  • Published 2015
  • Medicine, Biology
  • Physiological reviews
  • Spreading depression (SD) is a transient wave of near-complete neuronal and glial depolarization associated with massive transmembrane ionic and water shifts. It is evolutionarily conserved in the central nervous systems of a wide variety of species from locust to human. The depolarization spreads slowly at a rate of only millimeters per minute by way of grey matter contiguity, irrespective of functional or vascular divisions, and lasts up to a minute in otherwise normal tissue. As such, SD is… CONTINUE READING
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