Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature.

@article{Ayata2015SpreadingDS,
  title={Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature.},
  author={Cenk Ayata and Martin J Lauritzen},
  journal={Physiological reviews},
  year={2015},
  volume={95 3},
  pages={953-93}
}
Spreading depression (SD) is a transient wave of near-complete neuronal and glial depolarization associated with massive transmembrane ionic and water shifts. It is evolutionarily conserved in the central nervous systems of a wide variety of species from locust to human. The depolarization spreads slowly at a rate of only millimeters per minute by way of grey matter contiguity, irrespective of functional or vascular divisions, and lasts up to a minute in otherwise normal tissue. As such, SD is… CONTINUE READING