• Biology, Medicine
  • Published in
    American journal of human…
    2006
  • DOI:10.1086/503116

Spread of an inactive form of caspase-12 in humans is due to recent positive selection.

@article{Xue2006SpreadOA,
  title={Spread of an inactive form of caspase-12 in humans is due to recent positive selection.},
  author={Yali Xue and Allan Daly and Brynd{\'i}s Yngvad{\'o}ttir and Mengning M Liu and Graham Coop and Yuseob Kim and Pardis C Sabeti and Y. X. Chen and Jim Stalker and Elizabeth J. Huckle and John Burton and Steven Leonard and J. P. Rogers and Chris Tyler-Smith},
  journal={American journal of human genetics},
  year={2006},
  volume={78 4},
  pages={
          659-70
        }
}
The human caspase-12 gene is polymorphic for the presence or absence of a stop codon, which results in the occurrence of both active (ancestral) and inactive (derived) forms of the gene in the population. It has been shown elsewhere that carriers of the inactive gene are more resistant to severe sepsis. We have now investigated whether the inactive form has spread because of neutral drift or positive selection. We determined its distribution in a worldwide sample of 52 populations and… CONTINUE READING

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