Spread of an inactive form of caspase-12 in humans is due to recent positive selection.

@article{Xue2006SpreadOA,
  title={Spread of an inactive form of caspase-12 in humans is due to recent positive selection.},
  author={Y. Xue and A. Daly and Brynd{\'i}s Yngvad{\'o}ttir and M. Liu and G. Coop and Y. Kim and Pardis C Sabeti and Y. Chen and J. Stalker and E. Huckle and J. Burton and Steven Leonard and J. Rogers and C. Tyler-Smith},
  journal={American journal of human genetics},
  year={2006},
  volume={78 4},
  pages={
          659-70
        }
}
The human caspase-12 gene is polymorphic for the presence or absence of a stop codon, which results in the occurrence of both active (ancestral) and inactive (derived) forms of the gene in the population. It has been shown elsewhere that carriers of the inactive gene are more resistant to severe sepsis. We have now investigated whether the inactive form has spread because of neutral drift or positive selection. We determined its distribution in a worldwide sample of 52 populations and… Expand
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