Spray-drying Nanocapsules in Presence of Colloidal Silica as Drying Auxiliary Agent: Formulation and Process Variables Optimization Using Experimental Designs

@article{TewaTagne2006SpraydryingNI,
  title={Spray-drying Nanocapsules in Presence of Colloidal Silica as Drying Auxiliary Agent: Formulation and Process Variables Optimization Using Experimental Designs},
  author={Patrice Tewa-Tagne and Ghania Degobert and St{\'e}phanie Briançon and Claire Bordes and Jean-Yves Gauvrit and Pierre Lant{\'e}ri and Hatem Fessi},
  journal={Pharmaceutical Research},
  year={2006},
  volume={24},
  pages={650-661}
}
Spray-drying process was used for the development of dried polymeric nanocapsules. The purpose of this research was to investigate the effects of formulation and process variables on the resulting powder characteristics in order to optimize them. Experimental designs were used in order to estimate the influence of formulation parameters (nanocapsules and silica concentrations) and process variables (inlet temperature, spray-flow air, feed flow rate and drying air flow rate) on spray-dried… CONTINUE READING

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