Spray-dried powders as nasal absorption enhancers of cyanocobalamin.

@article{GarcaArieta2001SpraydriedPA,
  title={Spray-dried powders as nasal absorption enhancers of cyanocobalamin.},
  author={A. Garc{\'i}a-Arieta and S. Torrado-Santiago and L. Goya and J. Torrado},
  journal={Biological \& pharmaceutical bulletin},
  year={2001},
  volume={24 12},
  pages={
          1411-6
        }
}
The aim of this work is to describe and characterize a new spray-drying procedure for the production of nasal powders as an alternative to the conventional freeze-drying method. Cyanocobalamin was chosen as the active ingredient and loaded into five different nonsoluble vehicles with high water absorption ability. Then these hydrated particles were suspended in methylene chloride and spray-dried. Particle size, morphology, true, bulk and tapped density, percentage of compressibility, moisture… Expand
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References

SHOWING 1-10 OF 50 REFERENCES
Mucosal drug delivery using cellulose derivatives as a functional polymer.
  • Y. Suzuki, Y. Makino
  • Chemistry, Medicine
  • Journal of controlled release : official journal of the Controlled Release Society
  • 1999
TLDR
Results showed that the microenvironment of drugs in the functional base material could critically affect the nasal absorption of drugs. Expand
Spray-drying performance of a bench-top spray dryer for protein aerosol powder preparation.
TLDR
It is concluded that the modified spray-drying system is advantageous over the original bench-top spray dryer, and will be beneficial to early-stage research and development involving high-valued protein powders. Expand
Chitosans as nasal absorption enhancers of peptides: comparison between free amine chitosans and soluble salts.
TLDR
Both the free amine and the acid salt forms of chitosans are effective in enhancing the nasal absorption of [D-Arg(2)]-Kyotorphin and have potential for further studies as a safe and effective nasal absorption enhancer of peptide drugs. Expand
Bioadhesive microspheres as a potential nasal drug delivery system
Abstract The rapid mucociliary clearance mechanism in the nasal cavity can be considered as an important factor when low bioavailabilities are obtained for drugs given intranasally. A nasal deliveryExpand
Microspheres as a nasal delivery system for peptide drugs
Abstract Microspheres of starch and dextran, cross-linked with epichlorohydrine, function as an enhancer system for the absorption of insulin in rats. The effect on the glucose level is rapid andExpand
Evaluation of starch-maltodextrin-Carbopol 974 P mixtures for the nasal delivery of insulin in rabbits.
  • C. Callens, J. Remon
  • Chemistry, Medicine
  • Journal of controlled release : official journal of the Controlled Release Society
  • 2000
TLDR
In this study insulin was administered nasally to rabbits as a dry powder formulation and freeze-drying seemed a prerequisite for a good bioavailability from the powder formulation as well as the ratio of insulin versus bioadhesive powder. Expand
Evaluation of bile acids and fusidate derivative as nasal absorption enhancers using an electrophysiological technique.
TLDR
The results suggest that the reduction in membrane resistance and its reversibility appear to be due to a balance between the accumulation and clearance of STDHF. Expand
Powder dosage form of insulin for nasal administration
Abstract The present study was an attempt to develop a powder dosage form of insulin for nasal mucosal administration, and to investigate the effect of various excipients on the bioauail-ability ofExpand
Bioavailability of apomorphine following intranasal administration of mucoadhesive drug delivery systems in rabbits.
TLDR
Apomorphine was absorbed more rapidly in rabbits when administered intranasally than as a subcutaneous injection and the nasal bioavailability of powders is higher than that of solutions. Expand
Pharmaceutics : the science of dosage form design
Design of dosage forms. PART ONE SCIENTIFIC PRINICIPLES OF FORMULATION SCIENCE Solutions and their properties. Rheology and flow. Surface and interfacial phenomena. Solubility and dissolution rate.Expand
...
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2
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4
5
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