Spray dried amikacin powder for inhalation in cystic fibrosis patients: a quality by design approach for product construction.

@article{Belotti2014SprayDA,
  title={Spray dried amikacin powder for inhalation in cystic fibrosis patients: a quality by design approach for product construction.},
  author={Silvia Belotti and Alessandra Rossi and Paolo Colombo and Ruggero Bettini and Dimitrios M. Rekkas and Stavros N. Politis and Gaia Colombo and Anna Giulia Balducci and Francesca Buttini},
  journal={International journal of pharmaceutics},
  year={2014},
  volume={471 1-2},
  pages={
          507-15
        }
}
An amikacin product for convenient and compliant inhalation in cystic fibrosis patients was constructed by spray-drying in order to produce powders of pure drug having high respirability and flowability. An experimental design was applied as a statistical tool for the characterization of amikacin spray drying process, through the establishment of mathematical relationships between six Critical Quality Attributes (CQAs) of the finished product and five Critical Process Parameters (CPPs). The… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 23 CITATIONS

The application of Quality by Design framework in the pharmaceutical development of dry powder inhalers.

  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2017
VIEW 14 EXCERPTS
CITES METHODS

Nebulized coenzyme Q10 nanosuspensions: A versatile approach for pulmonary antioxidant therapy.

  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

Dose administration maneuvers and patient care in tobramycin dry powder inhalation therapy.

  • International journal of pharmaceutics
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND & METHODS

Formulation techniques for high dose dry powders.

  • International journal of pharmaceutics
  • 2018
VIEW 2 EXCERPTS
CITES METHODS