Spoxazomicin D and Oxachelin C, Potent Neuroprotective Carboxamides from the Appalachian Coal Fire-Associated Isolate Streptomyces sp. RM-14-6.

  title={Spoxazomicin D and Oxachelin C, Potent Neuroprotective Carboxamides from the Appalachian Coal Fire-Associated Isolate Streptomyces sp. RM-14-6.},
  author={Khaled A. Shaaban and Meredith A. Saunders and Yinan Zhang and Tuan Tran and Sherif I. Elshahawi and Larissa V. Ponomareva and Xiachang Wang and Jianjun Zhang and Gregory C. Copley and Manjula Sunkara and Madan K. Kharel and Andrew J. Morris and James C. Hower and Matthew S. Tremblay and Mark A. Prendergast and Jon S. Thorson},
  journal={Journal of natural products},
  volume={80 1},
The isolation and structure elucidation of six new bacterial metabolites [spoxazomicin D (2), oxachelins B and C (4, 5), and carboxamides 6-8] and 11 previously reported bacterial metabolites (1, 3, 9-12a, and 14-18) from Streptomyces sp. RM-14-6 is reported. Structures were elucidated on the basis of comprehensive 1D and 2D NMR and mass spectrometry data analysis, along with direct comparison to synthetic standards for 2, 11, and 12a,b. Complete 2D NMR assignments for the known metabolites… 

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