Spotlight on spotted mice: a review of white spotting mouse mutants and associated human pigmentation disorders.

@article{Baxter2004SpotlightOS,
  title={Spotlight on spotted mice: a review of white spotting mouse mutants and associated human pigmentation disorders.},
  author={Laura L Baxter and Ling Hou and Stacie K Loftus and William J. Pavan},
  journal={Pigment cell research},
  year={2004},
  volume={17 3},
  pages={215-24}
}
Mutation of genes that regulate neural crest-derived melanoblast development and survival can result in reduction and/or loss of mature melanocytes. The reduction in melanocyte number in the skin and hair follicles manifests itself as areas of hypopigmentation, commonly described as white spotting in mice. To date ten genes have been identified which are associated with white-spotting phenotypes in mouse. Seven of these genes are associated with neural crest and melanocyte disorders in humans… CONTINUE READING
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