Spotlight on Subcutaneous Recombinant Interferon-β-1a (Rebif®) in Relapsing-Remitting Multiple Sclerosis

@article{Murdoch2012SpotlightOS,
  title={Spotlight on Subcutaneous Recombinant Interferon-$\beta$-1a (Rebif{\textregistered}) in Relapsing-Remitting Multiple Sclerosis},
  author={David L. Murdoch and Katherine A. Lyseng-Williamson},
  journal={BioDrugs},
  year={2012},
  volume={19},
  pages={323-325}
}
Subcutaneous recombinant interferon-β-1a (Rebif®) 22 or 44μg three times weekly is a valuable option in the first-line treatment in patients with relapsing-remitting multiple sclerosis. It has shown benefits on outcome measures related to relapses, progression of disability, and magnetic resonance imaging in clinical trials. A significant efficacy advantage for subcutaneous interferon-β-1a three times weekly over intramuscular interferon-β-1a 30μg once weekly was shown at 24 and 48 weeks. The… 
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10 Citations
Background Citations
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Methods Citations
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10 Citations

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How optimizing glycosylation through a variety of glycoengineering strategies provides enticing opportunities to not only avoid past pitfalls, but also to substantially improve immunotherapies including antibodies and recombinant proteins, and cell-based therapies is described.
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An hADSC population stably overexpressed IFN‐β and LIF cytokines is successfully constructed and could be subjected for further evaluations in experimental autoimmune encephalomyelitis mice model.
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References

SHOWING 1-10 OF 24 REFERENCES
Haematological Effects of Interferon-β-1a (Rebif®) Therapy in Multiple Sclerosis
TLDR
Although haematological abnormalities are common and dose-related in patients with MS receiving interferon-β-1a, the events are mainly mild and transient, with little impact on adherence to therapy.
Long-Term Cost Effectiveness of Interferon-β-1a in the Treatment of Relapsing-Remitting Multiple Sclerosis
TLDR
This analysis indicated that IFNβ-1a 44μg subcutaneously three times weekly is cost effective in RRMS and that treatment becomes increasingly cost effective over time.
Randomized, comparative study of interferon β-1a treatment regimens in MS
TLDR
IFNβ-1a 44 μg subcutaneously tiw was more effective than IFNβ -1a 30 μg IM qw on all primary and secondary outcomes investigated after 24 and 48 weeks of treatment.
Hepatic Reactions During Treatment of Multiple Sclerosis with Interferon-β-1a
TLDR
Asymptomatic hepatic dysfunction is common in patients with multiple sclerosis who are treated with interferon-β-1a, and is dose related, with little impact on adherence to therapy, although rare serious events can occur.
Clinical importance of neutralising antibodies against interferon beta in patients with relapsing-remitting multiple sclerosis
Enhanced benefit of increasing interferon beta-1a dose and frequency in relapsing multiple sclerosis: the EVIDENCE Study.
TLDR
Patients receiving interferon beta-1a improved on clinical and MRI disease measures when they changed from 30 microg QW to 44 microg TIW, and had fewer active lesions on T2-weighted MRI compared with before the transition, whereas those continuing the 44-microgTIW regimen had no significant change in T2 active lesions.
PRISMS-4: Long-term efficacy of interferon-β-1a in relapsing MS
TLDR
Clinical and MRI benefit continued for both doses up to 4 years, with evidence of dose response, and outcomes were consistently better for patients treated for 4 years than for patients in crossover groups.
PRISMS-4: Long-term efficacy of interferon-&bgr;-1a in relapsing MS
TLDR
Clinical and MRI benefit continued for both doses up to 4 years, with evidence of dose response, and outcomes were consistently better for patients treated for 4 years than for patients in crossover groups.
Neutralizing antibodies to disease-modifying agents in the treatment of multiple sclerosis
TLDR
The potential development ofNAbs is an important consideration in selection and monitoring treatment of MS, and long-term prospective studies are needed to further define the clinical effects of NAbs on patients receiving disease-modifying therapies for MS.
A comparison of the mechanisms of action of interferon beta and glatiramer acetate in the treatment of multiple sclerosis.
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