Spotlight on Reteplase in Thrombotic Occlusive Disorders

  title={Spotlight on Reteplase in Thrombotic Occlusive Disorders},
  author={D. Simpson and M. A. Siddiqui and L. Scott and D. Hilleman},
  • D. Simpson, M. A. Siddiqui, +1 author D. Hilleman
  • Published 2012
  • Medicine
  • BioDrugs
  • Reteplase (Retavase®) is a plasminogen activator, mimicking endogenous tissue plasminogen activator (t-PA), a serine protease, converting plasminogen to plasmin and thereby precipitating thrombolysis. It is a third-generation recombinant form of t-PA that operates in the presence of fibrin (i.e. it is fibrin specific).Reteplase can be administered as a bolus dose (nonweight-based), rather than an infusion, which promotes rapid and safe administration. The ease of administration of this… CONTINUE READING
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