Sporozoite Immunization of Human Volunteers under Mefloquine Prophylaxis Is Safe, Immunogenic and Protective: A Double-Blind Randomized Controlled Clinical Trial

@inproceedings{Bijker2014SporozoiteIO,
  title={Sporozoite Immunization of Human Volunteers under Mefloquine Prophylaxis Is Safe, Immunogenic and Protective: A Double-Blind Randomized Controlled Clinical Trial},
  author={Else M. Bijker and Remko Schats and Joshua M. Obiero and Marije C Behet and Geert-Jan J. van Gemert and Marga G. van de Vegte-Bolmer and Wouter Graumans and Lisette van Lieshout and Guido J H Bastiaens and Karina Teelen and Cornelus Hermsen and Anja Scholzen and Leo G. Visser and Robert W. Sauerwein},
  booktitle={PloS one},
  year={2014}
}
Immunization of healthy volunteers with chloroquine ChemoProphylaxis and Sporozoites (CPS-CQ) efficiently and reproducibly induces dose-dependent and long-lasting protection against homologous Plasmodium falciparum challenge. Here, we studied whether chloroquine can be replaced by mefloquine, which is the only other licensed anti-malarial chemoprophylactic… CONTINUE READING