Sporn-( 4-Hydroxyphenyl ) retinamide N by Prevention of Primary Prostate Cancer in Lobund-Wistar Rats

@inproceedings{Pollard1991Sporn4,
  title={Sporn-( 4-Hydroxyphenyl ) retinamide N by Prevention of Primary Prostate Cancer in Lobund-Wistar Rats},
  author={Morris Pollard and Phyllis H. Luckert and Beckie Michael},
  year={1991}
}
We report for the first time that a synthetic retinoid, /V-(4-hydroxyphenyl)retinamide, can prevent the development of both primary and metastatic tumors in an animal model of metastasizing primary prostate cancer. Prostatic adenocarcinornas were induced in high incidence in Lobund-Wistar rats by initiation with methylnitrosourea i.v. and pro motion with testosterone. Feeding of Ar-(4-hydroxyphenyl)retinamide to these rats during the latency period markedly diminished the linai incidence of… CONTINUE READING