Sporadic reappearance of minute amounts of hepatitis C virus RNA after successful therapy stimulates cellular immune responses.

@article{Veerapu2011SporadicRO,
  title={Sporadic reappearance of minute amounts of hepatitis C virus RNA after successful therapy stimulates cellular immune responses.},
  author={Naga Suresh Veerapu and Sukanya Raghuraman and Tehming Liang and Theo Heller and Barbara Rehermann},
  journal={Gastroenterology},
  year={2011},
  volume={140 2},
  pages={676-685.e1}
}
BACKGROUND & AIMS Several studies have reported hepatitis C virus (HCV) RNA sequences in the circulation after treatment-induced or spontaneous recovery. We investigated whether the HCV RNA represents persistence of HCV infection or reinfection. METHODS We studied 117 patients who recovered from HCV infection (98 following therapy and 19 spontaneously). A reverse-transcription polymerase chain reaction assay was used to detect the 5'-untranslated region of HCV. T-cell responses were studied… CONTINUE READING

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