Sporadic inclusion body myositis: the genetic contributions to the pathogenesis

@article{Gang2014SporadicIB,
  title={Sporadic inclusion body myositis: the genetic contributions to the pathogenesis},
  author={Qiang Gang and Conceiç{\~a}o Bettencourt and Pedro M. Machado and Michael G. Hanna and Henry Houlden},
  journal={Orphanet Journal of Rare Diseases},
  year={2014},
  volume={9},
  pages={88 - 88}
}
Sporadic inclusion body myositis (sIBM) is the commonest idiopathic inflammatory muscle disease in people over 50 years old. It is characterized by slowly progressive muscle weakness and atrophy, with typical pathological changes of inflammation, degeneration and mitochondrial abnormality in affected muscle fibres. The cause(s) of sIBM are still unknown, but are considered complex, with the contribution of multiple factors such as environmental triggers, ageing and genetic susceptibility. This… 
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