Sporadic inclusion body myositis: Pathogenic considerations
@article{Karpati2009SporadicIB, title={Sporadic inclusion body myositis: Pathogenic considerations}, author={George Karpati and Erin O'ferrall}, journal={Annals of Neurology}, year={2009}, volume={65} }
Sporadic inclusion body myositis is the commonest acquired disease of skeletal muscles after 50 years of age, and as such it has commanded a great deal of attention of investigators over the past 25 years. As a result, a large amount of information has accumulated concerning its clinical profile, myopathology, and immunopathology. In the myopathology and immunopathology, there is general agreement that the characteristic features could be divided into a degenerative and an inflammatory group…
41 Citations
Sporadic inclusion body myositis: the genetic contributions to the pathogenesis
- Biology, MedicineOrphanet Journal of Rare Diseases
- 2014
This review summarizes the current understanding of the genetic contributions to sIBM and provides some insights for future research in this mysterious disease with the advantage of the rapid development of advanced genetic technology.
Idiopathic Inflammatory Myopathies: A Review of Immunopathological Features and Current Models of Pathogenesis
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The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of chronic systemic disorders characterized by muscle inflammation and progressive muscle weakness, and a growing body of evidence suggests that genetically susceptible individuals probably develop an idiopathy in response to particular environmental stimuli.
Idiopathic Inflammatory Myopathies: Clinical Approach and Management
- Medicine, BiologyFront. Neurol.
- 2016
A basic diagnostic approach to patients with suspected IIM is provided, current therapeutic strategies are summarized, and an insight into future prospective therapies is provided.
Inclusion body myositis
- Biology, MedicineCurrent opinion in rheumatology
- 2011
Sporadic inclusion body myositis understanding continues to advance, with progress regarding the mechanism of this disease.
Inclusion Body Myositis
- Medicine, BiologyContinuum
- 2016
The identification of a B-cell pathway has resulted in the first identification of an IBM autoantigen and emphasized its status as an autoimmune disease, and the recognition that large granular lymphocyte CD8+ T- cell expansions are present in both blood and muscle provides additional biomarkers for IBM and suggests a mechanistic relationship to the neoplastic disease T-cell large granules lymphocytic leukemia.
Inclusion body myositis in the rheumatology clinic
- Medicine, BiologyInternational journal of rheumatic diseases
- 2020
Inclusion body myositis is a rare sporadic inflammatory‐degenerative myopathy of the elderly. Despite being the commonest type of acquired myopathy after the age of 50, misdiagnosis is extremely…
Idiopathic inflammatory myopathies: current trends in pathogenesis, clinical features, and up-to-date treatment recommendations.
- Medicine, BiologyMayo Clinic proceedings
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Inclusion body myositis in a patient with long standing rheumatoid arthritis treated with anti-TNFα and rituximab
- Medicine, BiologyClinical Rheumatology
- 2009
The case of a 57-year-old patient with long standing rheumatoid arthritis who developed muscle wasting and weakness of the quadriceps femoris after initiation of anti-TNFα treatment is presented, underlines the therapeutic difficulties in IBM and suggests that anti- TNFα therapy might even be deleterious.
Sporadic Inclusion Body Myositis: Inflammatory and Degenerative Disease Mechanisms
- Biology
- 2011
It was shown that IFN-γ receptor protein expression on myofiber membranes correlated with the extent of inflammatory CD8+ T cell infiltrates surrounding the myofibers, whereas the ubiquitous HLA-I upregulation is triggered further upstream by as-yet-unknown mechanisms.
Theories of the Pathogenesis of Inclusion Body Myositis
- Biology, MedicineCurrent rheumatology reports
- 2010
Specific theories of its pathogenesis are reviewed and general considerations pertaining to modeling of this disease discussed, and the critical role of biomarkers and methodologic issues in their discovery are considered.
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