Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas.

@article{Hawkins2001SporadicCC,
  title={Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas.},
  author={Nicholas J. Hawkins and Robyn Lynne Ward},
  journal={Journal of the National Cancer Institute},
  year={2001},
  volume={93 17},
  pages={
          1307-13
        }
}
BACKGROUND Microsatellite instability (MSI) is seen in 10%-15% of sporadic colorectal cancers mostly in the right colon, but the precursors of cancers with MSI remain unknown. We examined whether sporadic cancers with MSI arise from pre-existing benign proliferative lesions (such as hyperplastic polyps or serrated adenomas [together denoted as "serrated polyps"]). METHODS The frequency of benign epithelial lesions (serrated polyps and conventional adenomas) was determined by histologic review… CONTINUE READING
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