Spontaneously immortalized epithelial cells from mouse caput epididymidis

  title={Spontaneously immortalized epithelial cells from mouse caput epididymidis},
  author={Aurore Britan and J J Lareyre and A-M. Lefrançois-Martinez and Mich{\`e}le Manin and Jo{\"e}l R. Drevet},
  journal={Molecular and Cellular Endocrinology},
We report here on the characterization of tissue-culture cell lines derived from primary cultures of the mouse caput epididymidis epithelium. The cell lines were spontaneously immortalized without the use of transforming oncogenes. In defined conditions, our epididymal cells adopted various morphological features that resembles that of the in vivo epididymis epithelium such as a polarized organization and the presence of junctional structures at their apical/lateral membranes as revealed by… CONTINUE READING