Spontaneously Hypertensive Rats (SHR) present deficits in prepulse inhibition of startle specifically reverted by clozapine

  title={Spontaneously Hypertensive Rats (SHR) present deficits in prepulse inhibition of startle specifically reverted by clozapine},
  author={R. Levin and M. Calzavara and C. M. Santos and W. Medrano and S. T. Niigaki and V. Ab{\'i}lio},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • R. Levin, M. Calzavara, +3 authors V. Abílio
  • Published 2011
  • Psychology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • Deficits in an operational measure of sensorimotor gating - the prepulse inhibition of startle (PPI) - are presented in psychiatric disorders such as schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD). Some previous studies showed that the spontaneously hypertensive rats (SHR) present PPI deficit. Although SHR is suggested as an animal model to study ADHD, we have suggested that the behavioral phenotype of this strain mimics some aspects of schizophrenia. The… CONTINUE READING
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