Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease

@inproceedings{Kaiser2014SpontaneousWM,
  title={Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease},
  author={Daniel Kaiser and Gesa Weise and Karoline M{\"o}ller and Johanna Scheibe and Claudia P{\"o}sel and Sebastian Baasch and Matthias Gawlitza and Donald Lobsien and K. -W. Diederich and Jens Minnerup and Alexander Kranz and Johannes Boltze and Daniel-Christoph Wagner},
  booktitle={Acta neuropathologica communications},
  year={2014}
}
INTRODUCTION Cerebral small vessel disease (cSVD) is one of the most prevalent neurological disorders. The progressive remodeling of brain microvessels due to arterial hypertension or other vascular risk factors causes subtle, but constant cognitive decline through to manifest dementia and substantially increases the risk for stroke. Preliminary evidence suggests the contribution of the immune system to disease initiation and progression, but a more detailed understanding is impaired by the… CONTINUE READING
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