Spontaneous tumour development in human papillomavirus type 8 E6 transgenic mice and rapid induction by UV-light exposure and wounding.

@article{Marcuzzi2009SpontaneousTD,
  title={Spontaneous tumour development in human papillomavirus type 8 E6 transgenic mice and rapid induction by UV-light exposure and wounding.},
  author={Gian Paolo Marcuzzi and Martin Hufbauer and Hans Udo Kasper and Soenke Jan Weissenborn and Sigrun Smola and Herbert Pfister},
  journal={The Journal of general virology},
  year={2009},
  volume={90 Pt 12},
  pages={2855-64}
}
Cutaneous human papillomavirus type 8 (HPV8) is carcinogenic in patients with epidermodysplasia verruciformis. Transgenic mice with the complete early region (CER) of HPV8 spontaneously developed papillomas, dysplasia and squamous cell carcinomas of the skin. To characterize the role of individual early genes in carcinogenesis, the E6 and E6/E7 genes were expressed separately in transgenic mice. Nearly all HPV8-E6-positive mice spontaneously developed multifocal tumours, characterized by… CONTINUE READING
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