Spontaneous thymoma rat as a model for myasthenic weakness caused by anti-ryanodine receptor antibodies.

@article{Iwasa1998SpontaneousTR,
  title={Spontaneous thymoma rat as a model for myasthenic weakness caused by anti-ryanodine receptor antibodies.},
  author={Kazuo Iwasa and Kiyonobu Komai and Masaharu Takamori},
  journal={Muscle & nerve},
  year={1998},
  volume={21 12},
  pages={1655-60}
}
The mechanism of muscle weakness in myasthenia gravis and its possible relation to antibodies that are directed against the ryanodine receptor (RyR) were studied by the use of the spontaneous thymoma rat (Buffalo/Mna strain). The present study focused on the motor dysfunction as complicated by impaired subcellular machineries and noted particularly in patients with thymus abnormalities. Rats began to develop skeletal muscle weakness soon after birth and worsened progressively. Rats aged 3… CONTINUE READING
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