Spontaneous spinal cerebrospinal fluid leaks and minor skeletal features of Marfan syndrome: a microfibrillopathy.

@article{Schrijver2002SpontaneousSC,
  title={Spontaneous spinal cerebrospinal fluid leaks and minor skeletal features of Marfan syndrome: a microfibrillopathy.},
  author={Iris Schrijver and W I Schievink and Maurice Godfrey and Fredric Bruce Meyer and Uta Francke},
  journal={Journal of neurosurgery},
  year={2002},
  volume={96 3},
  pages={
          483-9
        }
}
OBJECT Spontaneous spinal cerebrospinal fluid (CSF) leaks are increasingly recognized as a cause of postural headaches. The authors examined a group of patients suffering from spontaneous spinal CSF leaks who also had minor skeletal features of Marfan syndrome for abnormalities of fibrillin-containing microfibrils. METHODS Patients with spontaneous CSF leaks were evaluated for the clinical characteristics of connective tissue disorders. Skin biopsies were obtained in three patients with… CONTINUE READING
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