Spontaneous spheroid budding from monolayers: a potential contribution to ovarian cancer dissemination

@inproceedings{Pease2012SpontaneousSB,
  title={Spontaneous spheroid budding from monolayers: a potential contribution to ovarian cancer dissemination},
  author={Jillian C. Pease and Molly Brewer and Jennifer S. Tirnauer},
  booktitle={Biology open},
  year={2012}
}
Ovarian cancer is the most lethal gynaecologic cancer, in large part because of its early dissemination and rapid development of chemotherapy resistance. Spheroids are clusters of tumor cells found in the peritoneal fluid of patients that are thought to promote this dissemination. Current models suggest that spheroids form by aggregation of single tumor cells shed from the primary tumor. Here, we demonstrate that spheroids can also form by budding directly as adherent clusters from a monolayer… CONTINUE READING

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