Spontaneous secretion of tumor necrosis factor-beta by human myeloma cell lines.

@article{Bataille1989SpontaneousSO,
  title={Spontaneous secretion of tumor necrosis factor-beta by human myeloma cell lines.},
  author={R. and Bataille and Ursula Wohlfart and Michel Jourdan and Jean-François Rossi and Brian G. M. Durie},
  journal={Cancer},
  year={1989},
  volume={63 5},
  pages={
          877-80
        }
}
Abnormal bone remodelling in the vicinity of tumor cells is a common, early feature of multiple myeloma, characterized by excessive bone resorption which is mediated by local soluble factors called osteoclast activating factors (OAF). Since interleukin-1 (IL-1) and tumor necrosis factors (TNF) are potent, synergistic OAF produced by cells of the B-cell lineage, the authors investigated the spontaneous secretion of these cytokines by 11 human myeloma cell lines (HMCL). No HMCL secreted either IL… CONTINUE READING
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