Spontaneous secretion of IgG subclasses by intestinal mononuclear cells: differences between ulcerative colitis, Crohn's disease, and controls.

@article{Scott1986SpontaneousSO,
  title={Spontaneous secretion of IgG subclasses by intestinal mononuclear cells: differences between ulcerative colitis, Crohn's disease, and controls.},
  author={Monisha G. Scott and Moon H. Nahm and K A Macke and Goeffrey S. Nash and Michael J. Bertovich and Richard P Macdermott},
  journal={Clinical and experimental immunology},
  year={1986},
  volume={66 1},
  pages={209-15}
}
Spontaneous IgG and IgG subclass secretion patterns by isolated intestinal mononuclear cells (MNC) from control and inflammatory bowel disease (IBD) specimens were examined. Intestinal MNC from IBD specimens spontaneously secreted more total IgG than did control intestinal MNC. This increased spontaneous IgG secretion by ulcerative colitis intestinal MNC was primarily due to markedly increased production of IgG1. Slightly increased secretion of IgG3, but not IgG2 by ulcerative colitis… CONTINUE READING

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