Spontaneous sarcomere dynamics.

  title={Spontaneous sarcomere dynamics.},
  author={Stefan G{\"u}nther and Karsten Kruse},
  volume={20 4},
Sarcomeres are the basic force generating units of striated muscles and consist of an interdigitating arrangement of actin and myosin filaments. While muscle contraction is usually triggered by neural signals, which eventually set myosin motors into motion, isolated sarcomeres can oscillate spontaneously between a contracted and a relaxed state. We analyze a model for sarcomere dynamics, which is based on a force-dependent detachment rate of myosin from actin. Our numerical bifurcation analysis… Expand
Physics of muscle contraction.
The modeling approaches reviewed in this paper deal with both active and passive processes and support from the mechanical perspective the biological point of view that phenomena involved in slow (active) and fast (passive) force generation are tightly intertwined. Expand
Spontaneous oscillatory contraction (SPOC) in cardiomyocytes
Preliminary experiments showed that the SPOC properties of human cardiomyocytes are similar to the heartbeat of a large dog or a pig, which suggests that SPOCs may play a fundamental role in the heart. Expand
SPontaneous Oscillatory Contraction (SPOC): auto-oscillations observed in striated muscle at partial activation
SPOC (SPontaneous Oscillatory Contraction) is a less well-known third, intermediate state induced under conditions of partial activation, characterised by auto-oscillation between rapid-lengthening and slow-shortening phases and presents a novel technique for studying independent communication and coordination between sarcomeres. Expand
Subharmonic oscillations of collective molecular motors
We study a generic two-state model for an assembly of molecular motors which is described by means of a pair of integro-partial differential equations and leads to oscillatory motion in the presenceExpand
Analysis of spontaneous oscillations for a three-state power-stroke model.
The three-state power stroke model demonstrates that the dependence of the rate constants of the power and reversal strokes on the strains in the elastic elements in the motor molecules plays a key role, where these rate constants are rationally determined from the free energy available for the power stroke, the stiffness of the elastic element in the molecular motor, and the working stroke size. Expand
Symmetry breaking in regenerating hydra: the role of fluctuations and cell mechanics
F7 Naturwissenschaftlich-Tech. Fakultät II 7.2 Biologische Experimentalphysik Symmetry breaking in regenerating hydra: The role of fluctuations and cell mechanics
Introduction to focus issue: dynamics in systems biology.
This Focus Issue collects together a large variety of work which highlights the complementary nature of these two fields, showing what each has to offer the other. Expand


Spontaneous oscillatory contraction (SPOC) of sarcomeres in skeletal muscle.
The SPOC condition and the space-time pattern of SPOC wave suggest that the dynamics of association and dissociation of Pi (ADP) is regulated by the mechanical strain imposed on actin and myosin; the enzymatic activity (ATPase) of actomyosin complex and the mechanical event (contraction) are thus coupled to each other. Expand
Spontaneous waves in muscle fibres
By a macroscopic analysis of muscle fiber dynamics, a simple microscopic model of sarcomere dynamics highlights mechanical aspects of the motor dynamics and fits with the experimental observations. Expand
Spontaneous oscillations of a minimal actomyosin system under elastic loading.
It is shown that this minimal actomyosin system can oscillate spontaneously, and this finding accords quantitatively with a general theoretical framework where oscillatory instabilities emerge generically from the collective dynamics of molecular motors under load. Expand
Spontaneous oscillatory contraction of sarcomeres in skeletal myofibrils
The ‘state’-diagram showing the concentration range of ADP and Pi in which contraction, oscillation or relaxation of myofibrils occurs in the presence of ATP and the absence of Ca2+ suggested that the oscillation is a third state of skeletal muscle located in between the contracting and relaxing states. Expand
Molecular mechanism for oscillation in flagella and muscle.
  • C. Brokaw
  • Mathematics, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1975
Two-state models for muscle cross-bridges, of the type originally detailed by Andrew Huxley, were examined, to demonstrate that distribution of this type of local shear oscillation along the length of a flagellum is sufficient for the generation of propagated bending waves. Expand
Physical Aspects of Axonemal Beating and Swimming
We discuss a two-dimensional model for the dynamics of axonemal deformations driven by internally generated forces of molecular motors. Our model consists of an elastic filament pair connected byExpand
Generic aspects of axonemal beating
We study the dynamics of an elastic rod-like filament in two dimensions, driven by internally generated forces. This situation is motivated by cilia and flagella which contain an axoneme. TheseExpand
The Croonian Lecture, 1977 - Stretch activation of muscle: function and mechanism
  • J. Pringle
  • Biology, Medicine
  • Proceedings of the Royal Society of London. Series B. Biological Sciences
  • 1978
In insect fibrillar muscle, extension produces a maintained increase in actomyosin ATPase and active tension; in vertebrate skeletal muscle, stretch activation is a transient phenomenon and may play a rôle in Starling's Law. Expand
Spontaneous Oscillations of Collective Molecular Motors
We present a physical mechanism which can lead to oscillatory motion of molecular motors cooperating in large groups when the system is elastically coupled to its environment. Analytical andExpand
Oscillations in molecular motor assemblies.
  • A. Vilfan, E. Frey
  • Physics, Biology
  • Journal of physics. Condensed matter : an Institute of Physics journal
  • 2005
This work discusses systems with a delayed force activation and anomalous force-velocity relations within phase plane analysis known from the theory of dynamic systems and by adopting methods from control theory, the Nyquist stability criterion. Expand