Suppression of the Imprinted Gene NNAT and X-Chromosome Gene Activation in Isogenic Human iPS Cells
- Jonathan H. Teichroeb, Dean H. Betts, Homayoun Vaziri
- PloS one
- 2011
Highly Influenced
5 Excerpts
Spontaneous reversal of the developmental aging of normal human cells following transcriptional reprogramming.
- Published 2010 in Regenerative medicine
Abstract
AIM
To determine whether transcriptional reprogramming is capable of reversing the developmental aging of normal human somatic cells to an embryonic state.
MATERIALS & METHODS
An isogenic system was utilized to facilitate an accurate assessment of the reprogramming of telomere restriction fragment (TRF) length of aged differentiated cells to that of the… (More)