Spontaneous reversal of the developmental aging of normal human cells following transcriptional reprogramming.

Abstract

AIM To determine whether transcriptional reprogramming is capable of reversing the developmental aging of normal human somatic cells to an embryonic state. MATERIALS & METHODS An isogenic system was utilized to facilitate an accurate assessment of the reprogramming of telomere restriction fragment (TRF) length of aged differentiated cells to that of the… (More)
DOI: 10.2217/rme.10.21

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