Spontaneous reports of hypertension leading to hospitalisation in association with rofecoxib, celecoxib, nabumetone and oxaprozin.

@article{Brinker2004SpontaneousRO,
  title={Spontaneous reports of hypertension leading to hospitalisation in association with rofecoxib, celecoxib, nabumetone and oxaprozin.},
  author={Allen D. Brinker and Lawrence Goldkind and Renan A Bonnel and Julie Beitz},
  journal={Drugs & aging},
  year={2004},
  volume={21 7},
  pages={
          479-84
        }
}
BACKGROUND AND OBJECTIVE Data on file with the US FDA, and other published studies, suggest that the selective cyclo-oxygenase (COX)-2 inhibitor NSAID rofecoxib has a greater hypertensive adverse effect than other NSAIDs, including celecoxib. In this study we describe a pharmacoepidemiologic analysis of spontaneous adverse event reports of acute, clinically serious hypertension (as defined by hospitalisation) reported in association with rofecoxib, celecoxib, nabumetone and oxaprozin. The… CONTINUE READING
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