Spontaneous repopulation of β-catenin null livers with β-catenin-positive hepatocytes after chronic murine liver injury.

@article{Thompson2011SpontaneousRO,
  title={Spontaneous repopulation of β-catenin null livers with β-catenin-positive hepatocytes after chronic murine liver injury.},
  author={Michael D. Thompson and Emily Diane Wickline and William B Bowen and Amy Lu and Sucha Singh and Amalea Miss{\'e} and Satdarshan P. S. Monga},
  journal={Hepatology},
  year={2011},
  volume={54 4},
  pages={1333-43}
}
UNLABELLED Prolonged exposure of mice to diet containing 0.1% 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) results in hepatobiliary injury, atypical ductular proliferation, oval cell appearance, and limited fibrosis. Previously, we reported that short-term ingestion of DDC diet by hepatocyte-specific β-catenin conditional knockout (KO) mice led to fewer A6-positive oval cells than wildtype (WT) littermates. To examine the role of β-catenin in chronic hepatic injury and repair, we exposed WT… CONTINUE READING