Spontaneous regression of low-grade astrocytomas in childhood.

@article{Schmandt2000SpontaneousRO,
  title={Spontaneous regression of low-grade astrocytomas in childhood.},
  author={S M Schmandt and Roger J. Packer and L. Gilbert Vezina and John telephoned Jane},
  journal={Pediatric neurosurgery},
  year={2000},
  volume={32 3},
  pages={132-6}
}
An 8-year-old boy with neurofibromatosis type 1 (NF1) and a biopsy-proven juvenile pilocytic astrocytoma of the hypothalamic/chiasmatic region was followed with serial MRIs over 4 years. Spontaneous tumor regression was followed by progression and biopsy; 6 months later, the tumor regressed again. This bimodal regression is rare, but highlights the variable natural history of low-grade gliomas in children with NF1 and the difficulty in evaluating response of such tumors to therapy. 
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