Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice.

@article{Cui2003SpontaneousRO,
  title={Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice.},
  author={Zheng Cui and Mark C. Willingham and Amy M Hicks and Martha A Alexander-Miller and Timothy D. Howard and Gregory A Hawkins and Mark S. Miller and Holly M Weir and Wei Du and Cynthia Delong},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 11},
  pages={6682-7}
}
We have established and studied a colony of mice with a unique trait of host resistance to both ascites and solid cancers induced by transplantable cells. One dramatic manifestation of this trait is age-dependent spontaneous regression of advanced cancers. This powerful resistance segregates as a single-locus dominant trait, is independent of tumor burden, and is effective against cell lines from multiple types of cancer. During spontaneous regression or immediately after exposure, cancer cells… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
37 Citations
9 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

References

Publications referenced by this paper.
Showing 1-9 of 9 references

Nat. Immunol

  • G P Dunn, A T Bruce, H Ikeda, L J Old, R D Schreiber
  • Nat. Immunol
  • 2002

Nat. Med

  • L Gorelik, R A Flavell
  • Nat. Med
  • 2001

Trends Genet

  • A Balmain, H Nagase
  • Trends Genet
  • 1998

Vet. Immunol. Immunopathol

  • G Alfaro, C Lomeli, +4 authors G Nava
  • Vet. Immunol. Immunopathol
  • 1992

Acta Oncol

  • G B Challis, H J Stam
  • Acta Oncol
  • 1990

J. Surg. Oncol

  • W H Cole
  • J. Surg. Oncol
  • 1981

Cancer Res

  • G S Tarnowski, I M Mountain, C C Stock
  • Cancer Res
  • 1973

Prog. Clin. Cancer

  • T C Everson
  • Prog. Clin. Cancer
  • 1967

J. Immunol. Eur. J. Cancer Cell Tissue Kinet

  • J W Coffey, H J Hansen
  • J. Immunol. Eur. J. Cancer Cell Tissue Kinet
  • 1966

Similar Papers

Loading similar papers…