Spontaneous recovery of the decreased expression in vitro of interleukin 2 receptors in rheumatoid arthritis.

@article{PlaterZyberk1988SpontaneousRO,
  title={Spontaneous recovery of the decreased expression in vitro of interleukin 2 receptors in rheumatoid arthritis.},
  author={Christine Plater-Zyberk and Kirk A. Rockett and Ravinder N. Maini},
  journal={Clinical and experimental immunology},
  year={1988},
  volume={73 1},
  pages={93-7}
}
Peripheral blood mononuclear cells (PBM) from 11 patients with rheumatoid arthritis (RA) stimulated with 0.13 and 0.25 microgram/ml phytohaemagglutinin (PHA) for 3 days showed a depressed expression of interleukin 2 receptor (IL-2R) when compared with 14 normal controls (P less than 0.01). At these two doses of PHA a depressed lymphocyte proliferative response was also observed (P less than 0.01). However the kinetics of the response of the RA group differed from those of the control group… CONTINUE READING

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