Spontaneous reactivation of herpes simplex virus type 1 in latently infected murine sensory ganglia.

  title={Spontaneous reactivation of herpes simplex virus type 1 in latently infected murine sensory ganglia.},
  author={Todd Margolis and Fred L Elfman and David A. Leib and Nazzy Pakpour and Kathleen Apakupakul and Yumi Imai and Cindy Voytek},
  journal={Journal of virology},
  volume={81 20},
Careful studies of mouse trigeminal ganglia (TG) latently infected with herpes simplex virus type 1 (HSV-1) indicate the presence of productive cycle viral gene products and persistent immune response, suggesting ongoing spontaneous viral reactivation in these tissues. In the present study we set out to determine whether infectious virus is present in murine TG latently infected with HSV-1 (KOS). At 37 days after ocular inoculation we found a small amount of infectious virus in ca. 6% of… CONTINUE READING


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