Spontaneous production of Epstein-Barr virus by B lymphoblastoid cell lines obtained from patients with Sjögren's syndrome. Possible involvement of a novel strain of Epstein-Barr virus in disease pathogenesis.

@article{Tateishi1993SpontaneousPO,
  title={Spontaneous production of Epstein-Barr virus by B lymphoblastoid cell lines obtained from patients with Sj{\"o}gren's syndrome. Possible involvement of a novel strain of Epstein-Barr virus in disease pathogenesis.},
  author={Masahiro Tateishi and Ichiro Saito and Kazuhiko Yamamoto and Nobuyuki Miyasaka},
  journal={Arthritis and rheumatism},
  year={1993},
  volume={36 6},
  pages={827-35}
}
OBJECTIVE To investigate the involvement of Epstein-Barr virus (EBV) in the pathogenesis of Sjögren's syndrome (SS) and to examine whether the spontaneous production of EBV is unique to SS B cell lines. METHODS B cell lines were established from peripheral blood mononuclear cells (PBMC) of patients with systemic lupus erythematosus, rheumatoid arthritis, and SS. The cord blood immortalization assay, flow cytometric analysis, and polymerase chain reaction (PCR) were used to detect EBV… CONTINUE READING

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