Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity.

@article{Kirksey2011SpontaneousPD,
  title={Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity.},
  author={Meghan A. Kirksey and Anna D Tischler and Roxane Sim{\'e}one and Katherine B. Hisert and Swapna Uplekar and Christophe Guilhot and John D McKinney},
  journal={Infection and immunity},
  year={2011},
  volume={79 7},
  pages={2829-38}
}
Onset of the adaptive immune response in mice infected with Mycobacterium tuberculosis is accompanied by slowing of bacterial replication and establishment of a chronic infection. Stabilization of bacterial numbers during the chronic phase of infection is dependent on the activity of the gamma interferon (IFN-γ)-inducible nitric oxide synthase (NOS2). Previously, we described a differential signature-tagged mutagenesis screen designed to identify M. tuberculosis "counterimmune" mechanisms and… CONTINUE READING
22 Citations
33 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Similar Papers

Loading similar papers…