Spontaneous patterned retinal activity and the refinement of retinal projections

@article{Torborg2005SpontaneousPR,
  title={Spontaneous patterned retinal activity and the refinement of retinal projections},
  author={Christine L. Torborg and Marla B. Feller},
  journal={Progress in Neurobiology},
  year={2005},
  volume={76},
  pages={213-235}
}
Refinement of the retinogeniculate pathway
  • W. Guido
  • Biology
    The Journal of physiology
  • 2008
TLDR
The major changes in connectivity that occur in this mouse species and a potential mechanism that can account for such remodelling are outlined.
Spatial pattern of spontaneous retinal waves instructs retinotopic map refinement more than activity frequency
TLDR
It is suggested that propagating patterns of spontaneous retinal waves are essential for normal development of the retinotopic map, even while overall activity levels are significantly reduced, and support an instructive role for spontaneousretinal activity in both eye‐specific segregation and retinOTopic refinement.
Activity dependent mechanisms of visual map formation--from retinal waves to molecular regulators.
From Retinal Waves to Activity-Dependent Retinogeniculate Map Development
TLDR
A neural model is described of how spontaneous retinal waves are formed in infant mammals, and how these waves organize activity-dependent development of a topographic map in the lateral geniculate nucleus, with connections from each eye segregated into separate anatomical layers to provide a foundation for analyzing the temporal dynamics whereby the visual cortex itself develops.
Developmental Homeostasis of Mouse Retinocollicular Synapses
TLDR
In vitro recordings show that homeostasis arises from the conservation of total synaptic input from the retina, and that it is maintained via different mechanisms over development, suggesting that during the development of sensory maps, a unique consequence of homeostatic mechanisms is the precise shaping of neuronal receptive fields in conjunction with activity-dependent competition.
Retinal waves are likely to instruct the formation of eye-specific retinogeniculate projections
TLDR
The evidence that retinal waves play an instructive role in the development of visual responses is provided and it is argued that a full understanding requires an identification of the features of retinal activity that drive the refinement as well as an understanding of mechanisms that transform signals into axonal rearrangements.
Loss of binocular responses and reduced retinal convergence during the period of retinogeniculate axon segregation.
TLDR
A better understanding is provided of the underlying changes in synaptic circuitry that occur during the anatomical segregation of retinal inputs into eye-specific territories during the period of retinogeniculate axon segregation.
Consequences of axon guidance defects on the development of retinotopic receptive fields in the mouse colliculus
TLDR
Results are consistent with the effects of spontaneous retinal waves acting upon a disrupted molecular template, and they place significant limits on the form of an activity‐dependent learning rule for the development of retinocollicular projections.
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TLDR
It is shown that the spontaneous retinal activity present early in development provides information about the relative positions of retinal ganglion cells and can, in principle, be used at retinogeniculate and retinocollicular synapses to refine retinotopy.
The role of retinal waves and synaptic normalization in retinogeniculate development.
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TLDR
This model predicts that the more often one eye generates waves relative to the other eye, the more LGN units will monocularly respond to the more active eye, and finds that subtractive postsynaptic normalization is redundant and divisive presynapticnormalization is sufficient for normal development.
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TLDR
It is proposed that spontaneous activity in the ganglion cells is regulated by chemical inputs from both bipolar and amacrine cells and by gap junctional coupling involving ganglions, and that this regulates lamina-specific projections in the tectum.
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TLDR
It is shown that spontaneous retinal waves instruct retinotopic map refinement in the superior colliculus of the mouse, and how axon guidance cues and activity-dependent factors combine to instruct retinal map development is demonstrated.
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TLDR
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TLDR
This model produces spatially and temporally restricted waves without requiring inhibition, consistent with the early depolarizing action of neurotransmitters in the retina, and finds that highly correlated, temporally regular, and spatially restricted activity occurs over a range of network parameters.
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TLDR
The results suggest that the regulation of patterned spontaneous activity by neurotransmitters undergoes systematic change as new cellular elements are added to developing circuits and also that these new elements can help specify distinct activity patterns appropriate for shaping connectivity patterns at later ages.
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