Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A.

@article{MartnezChantar2002SpontaneousOS,
  title={Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A.},
  author={Mar{\'i}a L. Mart{\'i}nez-Chantar and Fernando Jos{\'e} Corrales and Luis Alfonso Mart{\'i}nez-Cruz and Elena Ruiz Garc{\'i}a-Trevijano and Z Z Huang and Li-xin Chen and G. I. Kanel and Mat{\'i}as A. Avila and Jose M. Mato and Shelly C. Lu},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2002},
  volume={16 10},
  pages={1292-4}
}
In mammals, methionine metabolism occurs mainly in the liver via methionine adenosyltransferase-catalyzed conversion to S-adenosylmethionine. Of the two genes that encode methionine adenosyltransferase(MAT1Aand MAT2A), MAT1A is mainly expressed in adult liver whereas MAT2A is expressed in all extrahepatic tissues. Mice lacking MAT1A have reduced hepatic S-adenosylmethionine content and hyperplasia and spontaneously develop nonalcoholic steatohepatitis. In this study, we examined whether chronic… CONTINUE READING
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