Spontaneous neutrophil apoptosis involves caspase 3-mediated activation of protein kinase C-delta.

@article{Pongrcz1999SpontaneousNA,
  title={Spontaneous neutrophil apoptosis involves caspase 3-mediated activation of protein kinase C-delta.},
  author={Judit E. Pongr{\'a}cz and Paul D. Webb and Kaihua Wang and Elizabeth M Deacon and O J Lunn and John Michael Lord},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 52},
  pages={37329-34}
}
Neutrophils are short-lived leukocytes that die by apoptosis. Whereas stress-induced apoptosis is mediated by the p38 mitogen-activated protein (MAP) kinase pathway (Frasch, S. C., Nick, J. A., Fadok, V. A., Bratton, D. L., Worthen, G. S., and Henson, P. M. (1998) J. Biol. Chem. 273, 8389-8397), signals regulating spontaneous neutrophil apoptosis have not been fully determined. In this study we found increased activation of protein kinase C (PKC)-beta and -delta in neutrophils undergoing… CONTINUE READING