Spontaneous neuronal calcium spikes and waves during early differentiation.

  title={Spontaneous neuronal calcium spikes and waves during early differentiation.},
  author={Xiaonan Gu and Edith C S Olson and Nicholas C. Spitzer},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={14 11 Pt 1},
Calcium ions play critical roles in neuronal development, but the factors that govern spontaneous fluctuations in intracellular calcium are not well understood. Transient, repeated elevations of calcium in embryonic Xenopus spinal neurons have been recorded over periods of 1 hr in vitro and in vivo, confocally imaging fluo-3-loaded cells at 5 sec intervals. Calcium spikes and calcium waves are found both in neurons in culture and in the intact spinal cord. Spikes rise rapidly to approximately… CONTINUE READING
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