Spontaneous mutation rates at enzyme loci in Drosophila melanogaster.

@article{Mukai1977SpontaneousMR,
  title={Spontaneous mutation rates at enzyme loci in Drosophila melanogaster.},
  author={Terumi Mukai and C. Clark Cockerham},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1977},
  volume={74 6},
  pages={2514-7}
}
In a marked-inversion-balanced lethal system mutations were accumulated at a minimum pressure of natural selection on 2000 second chromosomes of Drosophila melanogaster that originated from 4 stem chromosomes. Five enzyme loci were tested: alpha-glycerol-3-phosphate dehydrogenase (EC 1.1.1.8), malate dehydrogenase (Mdh, EC 1.1.1.37), alcohol dehydrogenase (EC 1.1.1.1), hexokinase-C (Hex-C tentative name), and alpha-amylase (Amy, EC 3.2.1.1). Three band-morph mutants, one at the Mdh locus, one… CONTINUE READING

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