Spontaneous mutation in the Escherichia coli lacI gene.

  title={Spontaneous mutation in the Escherichia coli lacI gene.},
  author={Roel M. Schaaper and Ronnie L Dunn},
  volume={129 2},
To gain more detailed insight into the nature and mechanisms of spontaneous mutations, we undertook a DNA sequence analysis of a large collection of spontaneous mutations in the N-terminal region of the Escherichia coli lacI gene. This region of circa 210 base pairs is the target for dominant lacI mutations (i-d) and is suitable for studies of mutational specificity since it contains a relatively high density of detectable mutable sites. Among 414 independent i-d mutants, 70.8% were base… CONTINUE READING

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