Spontaneous mutation in lacI transgenic mice: a comparison of tissues.

@article{Boer1998SpontaneousMI,
  title={Spontaneous mutation in lacI transgenic mice: a comparison of tissues.},
  author={Johan G de Boer and Scott Provost and Norrie Gorelick and Kenneth Raymond Tindall and Barry W. Glickman},
  journal={Mutagenesis},
  year={1998},
  volume={13 2},
  pages={
          109-14
        }
}
The nature of spontaneous mutations in the lacI transgene of Big Blue mice was determined in selected tissues. The mutant frequencies ranged from 2.5 x 10(-5) to 7.1 x 10(-5) for liver, spleen, bladder, stomach, kidney, bone marrow, lung and skin. We also determined the DNA sequence alterations in the mutants recovered from these tissues. In all tissues the predominant class of mutations was G:C-->A:T transitions, most of which occurred at 5'-CpG-3' dinucleotide sequences. Bladder, kidney and… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 17 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

The Spectrum of spontaneous

  • K. R. Tindall, Glickman.B.W
  • 1997

The Spectrum of spontaneous mutants in liver tissue of lael transgenic mice

  • H. MillerJ.
  • Environ . Mol Mutagen .
  • 1997

MillerJ. and Pippert.T

  • T. R. Skopek, Mario.D.R, Kort, L K
  • Mutat. Res.,
  • 1996
1 Excerpt

Synthesis of a lacl gene analogue with reduced CpG content

  • R. Y.-H Wang, C Kuo.K., C. W. Gehrke, L.-H. Huang, M Ehrlich.
  • Mutat . Res .
  • 1996

The spectrum of mutations in kidney , stomach and liver from lael transgenic mice , recovered after treatment with tris ( 2 , 3 - dibromopropyl ) phosphate

  • G. DeBoerJ., H. Erfle., +4 authors W. Glickman.B.
  • Environ . Mol Mutagen .
  • 1996

Similar Papers

Loading similar papers…